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Metformin Trade Names: Glucophage, Glucophage XR Drug Class: oral hypoglycemic, biguanide Mechanism of Action: via activation of AMP-activated protein kinase (AMPK)(see Figure 1)

MCI: Mild Cognitive Impairment refers to a condition that falls between the normal cognitive changes associated with aging and more severe cognitive decline seen in dementia

The results showed that more patients in the combination group achieved the primary outcome and resolution of MASH than did those in the placebo group, while there was no significant difference between the vitamin and placebo groups, suggesting the beneficial effect of pioglitazone on MASH

In: Pareek A, Sopory SK, Bohnert JH, Govindjee, editors